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HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci
- Source :
- Molecular Biology and Evolution. 15:1581-1588
- Publication Year :
- 1998
- Publisher :
- Oxford University Press (OUP), 1998.
-
Abstract
- The HLA complex includes the most polymorphic genes in the human genome. However, the HLA class Ib loci have little, if any, nucleotide variation, presumably due to their specialized functions or perhaps due to a lack of function. This population genetic study of HLA-H, a class I pseudogene, was initiated to determine the pattern of variation at neutral sites within the HLA complex. We found that the pattern of variation for HLA-H is consistent with the neutral model. However, the amount of variation in HLA-H is significantly greater than estimates for other silent sites within the human genome outside of the MHC (theta = 0.0144, P < 0.000001). Our study further indicates that other possible causes of increased variation such as a high mutation rate for HLA-H, interlocus gene conversion, increased diversity in the sample population in general, and selection acting directly on HLA-H are unlikely. Instead, these data suggest that HLA-H has increased variation as a result of balancing selection acting on nearby loci such as HLA-A.
- Subjects :
- Mutation rate
Pan troglodytes
Pseudogene
Population
Black People
Human leukocyte antigen
Balancing selection
Major histocompatibility complex
Cell Line
Evolution, Molecular
Major Histocompatibility Complex
HLA Antigens
Pongo pygmaeus
Genetics
Animals
Humans
Gene conversion
Selection, Genetic
Hemochromatosis Protein
education
Molecular Biology
Ecology, Evolution, Behavior and Systematics
HLA Complex
DNA Primers
education.field_of_study
Gorilla gorilla
Polymorphism, Genetic
biology
Genome, Human
Histocompatibility Antigens Class I
Membrane Proteins
Exons
Pan paniscus
Introns
biology.protein
Pseudogenes
Subjects
Details
- ISSN :
- 15371719 and 07374038
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Molecular Biology and Evolution
- Accession number :
- edsair.doi.dedup.....753e3f5598279b300c7de30d156be9f4