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Stereotactic subthalamic nucleus lesioning for the treatment of Parkinson's disease
- Source :
- Stereotactic and functional neurosurgery. 77(1-4)
- Publication Year :
- 2002
-
Abstract
- This study was performed to evaluate the effectiveness and safety of unilateral STN lesioning in 23 patients with PD. L-Dopa intake and dyskinesia, Hoehn & Yahr, Schwab & England, and UPDRS motor scores were recorded pre- and postoperatively. Stereotactic MRI and CT and macrostimulation were used to establish target coordinates. A single RF lesion was performed. All patients underwent postoperative MRI. Contralateral tremor arrest and decrease of rigidity and bradykinesia should be regarded as hallmarks to STN stimulation. All recorded parameters were significantly improved after a mean follow-up of 13.5 months. Patients with STN lateral territory lesioning (α 0.05) did better than the others. The recurrence rate was 10%. Two patients developed dyskinesias which were completely resolved by a Vim/VOp lesion. Other significant complications were rare. The authors conclude that unilateral STN lesioning is a safe and very effective procedure to treat PD.
- Subjects :
- Male
Parkinson's disease
Stereotactic surgery
Deep brain stimulation
medicine.medical_treatment
Severity of Illness Index
Lesion
Antiparkinson Agents
Levodopa
Stereotaxic Techniques
Recurrence
Subthalamic Nucleus
otorhinolaryngologic diseases
Electrocoagulation
Medicine
Humans
Prospective Studies
Confusion
Dyskinesias
business.industry
Dysarthria
Parkinson Disease
Middle Aged
medicine.disease
Combined Modality Therapy
Magnetic Resonance Imaging
humanities
Electric Stimulation
nervous system diseases
Subthalamic nucleus
surgical procedures, operative
Treatment Outcome
Dyskinesia
Anesthesia
Surgery
Female
Neurology (clinical)
medicine.symptom
Safety
business
Tomography, X-Ray Computed
human activities
Subjects
Details
- ISSN :
- 10116125
- Volume :
- 77
- Issue :
- 1-4
- Database :
- OpenAIRE
- Journal :
- Stereotactic and functional neurosurgery
- Accession number :
- edsair.doi.dedup.....753d46a984d6b5d42b5e82f0e442ce65