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[Chronic recurrent multifocal osteomyelitis with interstitial myositis]
- Source :
- Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 36(1)
- Publication Year :
- 2013
-
Abstract
- Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious disorder of skeletal system mainly seen in children. We report a case of CRMO presenting with fever and leg pain. The patient was an 11-year-old boy complaining of a fever, swelling and pain on his right foot, and pain on both legs. Although serum levels of CK and aldolase were not increased, MRI imaging suggested polymyositis. Muscle biopsy showed interstitial infiltration of inflammatory cells without any evidences of dermatomyositis or polymyositis. One month later, he complained of a swelling, pain and redness of his left clavicle as recurrently experienced during the recent 6 months, and MRI investigation indicated the diagnosis of osteomyelitis. Bone biopsy was performed and showed chronic inflammatory changes with negative bacterial culture. Multiple bone lesions and muscle uptake of FDG in his legs were revealed by whole body FDG-PET/CT, and he was diagnosed as having CRMO with interstitial myositis. The combinatorial administration of non-steroidal anti-inflammatory drugs and bisphosphonate successfully improved his clinical symptoms and laboratory abnormalities. To our knowledge, there is no report of a patient of CRMO associated with interstitial myositis.
- Subjects :
- Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Immunology
Interstitial Myositis
Polymyositis
Recurrence
medicine
Immunology and Allergy
Humans
Child
Muscle biopsy
medicine.diagnostic_test
Bone Density Conservation Agents
Diphosphonates
business.industry
Osteomyelitis
Chronic recurrent multifocal osteomyelitis
Anti-Inflammatory Agents, Non-Steroidal
Magnetic resonance imaging
General Medicine
Dermatomyositis
Bisphosphonate
medicine.disease
Magnetic Resonance Imaging
Treatment Outcome
Positron-Emission Tomography
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 13497413
- Volume :
- 36
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
- Accession number :
- edsair.doi.dedup.....753bd3356c5b8af4e016f79f469baa98