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2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic
- Source :
- Life Sciences. 78:1392-1399
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- 2-Deoxyglucose (2-DG), a non-metabolizable glucose analogue, blocks glycolysis and inhibits protein glycosylation. It has been tested in multiple studies for possible application as an anticancer or antiviral therapeutic. The inhibitory effect of 2-DG on ATP generation made it a good candidate molecule as a calorie restriction mimetic as well. Furthermore, 2-DG has been utilized in numerous studies to simulate a condition of glucose starvation. Because 2-DG disrupts glucose metabolism, protein glycosylation, and ER quality control at the same time, a cellular or pathologic outcome could be easily misinterpreted without clear understanding of 2-DG's effect on each of these aspects. However, the effect of 2-DG on protein glycosylation has rarely been investigated. A recent study suggested that 2-DG causes hyperGlcNAcylation of proteins, while low glucose supply causes hypoGlcNAcylation. In certain aspects of cellular physiology, this difference could be disregarded, but in others, this may possibly cause totally different outcomes.
- Subjects :
- Cell physiology
Glycosylation
Acylation
Deoxyglucose
Calorie restriction
Antineoplastic Agents
General Medicine
Biology
Carbohydrate metabolism
Antiviral Agents
General Biochemistry, Genetics and Molecular Biology
Low glucose
Biochemistry
Transcription (biology)
Animals
Humans
Glycolysis
General Pharmacology, Toxicology and Pharmaceutics
Energy Intake
Inhibitory effect
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....75317728a24e04c558789f3e01c6d659