Substances derived from 4-de-N-methylfortimicin B

Authors :: Momir Cirovic
Ruth S. Stanaszek
Paul Kurath
Richard S. Egan
William H. Washburn
James E. Leonard
Dave Grampovnik
Paulette Johnson
Jack Tadanier
Source :: The Journal of Antibiotics. 34:691-700
Publication Year :: 1981
Publisher :: Japan Antibiotics Research Association, 1981.
Abstract: The preparation of 4-de-N-methylfortimicin A analogs as well as the preparation of 4-de-N-methyl-4-N-(beta-aminoethyl)-4-N-ethylfortimicin B is reported. It was shown that the 4-N-methyl group in fortimicin analogs is essential for antibacterial activity since neither the 4-de-N-methylfortimicin A nor the 4-de-N-methyl-4-N-(beta-aminoethyl)-4-N-ethylfortimicin B exhibited useful biological activity.