Back to Search
Start Over
Radiofrequency Ablation of Functioning Adrenal Adenomas: Preliminary Clinical and Laboratory Findings
- Source :
- Journal of Vascular and Interventional Radiology. 26:1459-1464
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Purpose To evaluate clinical and laboratory findings in patients undergoing radiofrequency (RF) ablation for functioning adrenal adenomas. Materials and Methods Eleven adult patients, nine with Conn syndrome and two with Cushing syndrome, underwent percutaneous computed tomography–guided RF ablation for benign adrenal neoplasms. Systolic, diastolic, and mean blood pressure and the number of classes of antihypertensive drugs used by each patient were analyzed before and 1, 4, and 12 weeks after the procedure. Serum hormone levels were analyzed within 30 days before and 12 weeks after the procedure. Results Of the nine patients with Conn syndrome, eight showed normal serum aldosterone levels after the procedure and one patient had a nodule located very close to the inferior vena cava, resulting in incomplete ablation. The two patients with Cushing syndrome had normal serum and salivary cortisol levels after the procedure. Mean aldosterone concentration at baseline was 63.3 ng/dL ± 28.0 and decreased to 13.3 ng/dL ± 13.5 at 12 weeks postoperatively ( P = .008). Systolic, diastolic, and mean blood pressures decreased significantly in the first week after the procedure ( P Conclusions In patients with Conn syndrome or Cushing syndrome, percutaneous RF ablation of functioning adrenal adenomas may result in normalization of hormone secretion, improvement in blood pressure, and reduced need for antihypertensive drugs.
- Subjects :
- Adenoma
Adult
Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Adrenal Gland Neoplasms
Urology
Pilot Projects
Catheter ablation
Adrenal neoplasm
Inferior vena cava
Cushing syndrome
chemistry.chemical_compound
medicine
Humans
Conn Syndrome
Radiology, Nuclear Medicine and imaging
Aldosterone
business.industry
Middle Aged
medicine.disease
Treatment Outcome
Blood pressure
Surgery, Computer-Assisted
medicine.vein
chemistry
Catheter Ablation
Female
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 10510443
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Vascular and Interventional Radiology
- Accession number :
- edsair.doi.dedup.....752241639c8c00eb8c52c44234bd3687