Back to Search
Start Over
Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer
- Source :
- Cancer Lett
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Esophageal cancer (EC) has been a leading cause of cancer death worldwide in part due to late detection and lack of precision treatment. EC includes two major malignancies, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Recent studies reveal that ESCC and EAC have distinct cell of origin and contain cancer stem cells (also known as tumor initiating cells) expressing different cell surface markers. These biomarkers have potentially important values for both early detection and finding effective therapy. In this review we summarize the updated findings for cell of origin and provide an overview of cancer cell biomarkers that have been tested for ESCC and EAC. In addition, we also discuss recent progress in the study of molecular mechanisms leading to these malignancies.
- Subjects :
- 0301 basic medicine
Cancer Research
Esophageal Neoplasms
Cell of origin
Esophageal adenocarcinoma
Adenocarcinoma
Article
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Biomarkers, Tumor
Animals
Humans
Medicine
Cluster of differentiation
business.industry
Esophageal cancer
medicine.disease
digestive system diseases
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Barrett's esophagus
Cancer cell
Neoplastic Stem Cells
Etiology
Cancer research
Esophageal Squamous Cell Carcinoma
business
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 458
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....7521999f2fd82afd281e4e8c11333b25