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Levels of circulating nitrate/nitrite and gamma interferon not increased in uncomplicated malaria
- Source :
- Scopus-Elsevier
-
Abstract
- The purpose of this study was to evaluate nitric oxide (NO) activity in patients with uncomplicated malaria. Lipopolysaccharide and gamma interferon (IFN-gamma) are potent inducers of NO by inducing production of NO synthase. NO activity was determined by measuring serum levels of nitrite/nitrate (metabolic end products of NO), and IFN-gamma in patients with uncomplicated malaria, mostly caused by Plasmodium falciparum. Neither serum levels of nitrite/nitrate nor of IFN-gamma were significantly increased in patients with uncomplicated malaria, especially in patients with P. falciparum infection, and in those with high parasitaemia. These results show that NO cannot play a role in uncomplicated malaria, and it is still debatable if NO production in this infection has beneficial or detrimental effects.
- Subjects :
- Microbiology (medical)
Adult
Lipopolysaccharide
medicine.medical_treatment
Parasitemia
Biology
Nitric Oxide
Nitric oxide
chemistry.chemical_compound
Interferon-gamma
Nitrate
parasitic diseases
medicine
Humans
Interferon gamma
Nitrite
Malaria, Falciparum
Nitrites
Nitrates
General Medicine
Middle Aged
medicine.disease
Malaria
Infectious Diseases
Cytokine
chemistry
Immunology
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....7516f3b674197d338d36d91cf4e4e41e