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Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape
- Source :
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 203
- Publication Year :
- 2017
-
Abstract
- In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-assembly. The conjugates of complex 3 (with both gold nanorods (AuNR) and nanospheres (AuNS)), displayed decreased fluorescence quantum yield with corresponding improved triplet and singlet quantum yields compared to complex 3 alone, however 3-AuNR showed improved properties than 3-AuNS. Complex 3 showed relatively low in vitro dark cytotoxicity against the epithelial breast cancer cells with cell survival ≥ 85% at concentration ≤ 160 μg/mL but afforded reduced photodynamic therapy activity which may be due to aggregation. 3-AuNR afforded superior PDT activity with50% viable cells at concentration ≥ 40 μg/mL in comparison to 3-AuNS with50% viable cells at concentration ≥ 80 μg/mL. The superior activity of 3-AuNR is attributed to the photothermal therapy effect since nanorods absorb more light at 680 nm than nanospheres.
- Subjects :
- Glycosylation
Indoles
medicine.medical_treatment
Nanoparticle
Quantum yield
chemistry.chemical_element
Metal Nanoparticles
Photodynamic therapy
02 engineering and technology
Zinc
Isoindoles
010402 general chemistry
01 natural sciences
Analytical Chemistry
X-Ray Diffraction
Spectroscopy, Fourier Transform Infrared
medicine
Organometallic Compounds
Humans
Singlet state
Instrumentation
Spectroscopy
Singlet Oxygen
Chemistry
Photoelectron Spectroscopy
Spectrometry, X-Ray Emission
021001 nanoscience & nanotechnology
Combinatorial chemistry
Atomic and Molecular Physics, and Optics
0104 chemical sciences
Photochemotherapy
Colloidal gold
Zinc Compounds
MCF-7 Cells
Quantum Theory
Nanorod
Spectrophotometry, Ultraviolet
Gold
0210 nano-technology
Conjugate
Subjects
Details
- ISSN :
- 18733557
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
- Accession number :
- edsair.doi.dedup.....7507d19d031e67acc2507ce04278b400