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ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
- Source :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
- Publication Year :
- 2019
-
Abstract
- Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrate that ITLN1 suppresses lactotransferrin’s effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells. Additionally, ovarian cancer-bearing mice treated with ITLN1 demonstrate marked decrease in tumor growth rates. These data suggest that downregulation of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progression.<br />Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progression.
- Subjects :
- 0301 basic medicine
MMP1
endocrine system diseases
General Physics and Astronomy
Carcinoma, Ovarian Epithelial
Mice
Prognostic markers
0302 clinical medicine
Cell Movement
Lectins
Tumor Microenvironment
lcsh:Science
Peritoneal Neoplasms
Ovarian Neoplasms
Multidisciplinary
female genital diseases and pregnancy complications
Recombinant Proteins
Lactotransferrin
Gene Expression Regulation, Neoplastic
Survival Rate
medicine.anatomical_structure
Cell Transformation, Neoplastic
030220 oncology & carcinogenesis
Cytokines
Female
Matrix Metalloproteinase 1
Omentum
endocrine system
Science
Down-Regulation
Ovary
GPI-Linked Proteins
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
Downregulation and upregulation
Ovarian cancer
Cell Line, Tumor
medicine
Carcinoma
Animals
Humans
Neoplasm Invasiveness
Survival rate
Cell Proliferation
Tumor microenvironment
business.industry
General Chemistry
medicine.disease
Disease Models, Animal
Lactoferrin
030104 developmental biology
Cancer research
lcsh:Q
business
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....75016bf2adfe02f4b65e1ff869277968