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Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells

Authors :
Allan B. Dietz
Nneka I. Comfere
Thomas E. Witzig
Stephen M. Ansell
Steven C. Ziesmer
Mark R. Pittelkow
Andrew L. Feldman
Sherine F. Elsawa
Ryan A. Wilcox
Anne J. Novak
David A. Wada
Source :
Blood. 114:2936-2944
Publication Year :
2009
Publisher :
American Society of Hematology, 2009.

Abstract

A variety of nonmalignant cells present in the tumor microenvironment promotes tumorigenesis by stimulating tumor cell growth and metastasis or suppressing host immunity. The role of such stromal cells in T-cell lymphoproliferative disorders is incompletely understood. Monocyte-derived cells (MDCs), including professional antigen-presenting cells such as dendritic cells (DCs), play a central role in T-cell biology. Here, we provide evidence that monocytes promote the survival of malignant T cells and demonstrate that MDCs are abundant within the tumor microenvironment of T cell–derived lymphomas. Malignant T cells were observed to remain viable during in vitro culture with autologous monocytes, but cell death was significantly increased after monocyte depletion. Furthermore, monocytes prevent the induction of cell death in T-cell lymphoma lines in response to either serum starvation or doxorubicin, and promote the engraftment of these cells in nonobese diabetic/severe combined immunodeficient mice. Monocytes are actively recruited to the tumor microenvironment by CCL5 (RANTES), where their differentiation into mature DCs is impaired by tumor-derived interleukin-10. Collectively, the data presented demonstrate a previously undescribed role for monocytes in T-cell lymphoproliferative disorders.

Details

ISSN :
15280020 and 00064971
Volume :
114
Database :
OpenAIRE
Journal :
Blood
Accession number :
edsair.doi.dedup.....74fa4583398e646667a46edc74706133
Full Text :
https://doi.org/10.1182/blood-2009-05-220111