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Biologically equivalent substitutive technology: what is needed to manufacture pluripotent stem cells for next-generation platforms for discovery and therapy
- Source :
- Regenerative Medicine. 8:519-521
- Publication Year :
- 2013
- Publisher :
- Future Medicine Ltd, 2013.
-
Abstract
- The unparalleled breadth of human embryo and induced pluripotent stem cell competence for growth and differentiation is the cornerstone upon which aspirations to use these cells to develop next-generation platforms for discovery and therapy are based. To date, research has predominantly focused on understanding the intrinsic and extrinsic determinants of these competences from the study of development and tissue homeostasis. However, in order to progress this knowledge to the point of actually delivering on the applications in drug discovery and regenerative medicine, commonly promised by academic scientists in the field, it is necessary to improve the efficacy, safety and cost–effectiveness of the systems that currently exist to cultivate them. This begins with the frank acknowledgement that pluripotent stem cells, and all cells that are derived from them, are and will always be artefacts of culture. Thus, although knowledge of mechanisms governing cell lineage specification and behavior in developing and formed tissues is certainly an important foundation upon which to base manipulations – this knowledge can also unnecessarily limit paradigms for how to control the growth and differentiation of pluripotent stem cells ex vivo. This is made clear by the resounding success of genetic and chemical manipulations that can induce a pluripotent cell phenotype in the first place, and corollary achievements in direct cell conversion, which forces a rethink of long-held dogma concerning cell fate hierarchies [1]. The efficacy, safety and cost–effectiveness of any cell culture system hinges on the quality and consistency of the components upon which it is based, which ultimately relies on the extent to which they are biochemically and physically defined, affordably manufactured and available.
- Subjects :
- Pluripotent Stem Cells
Embryology
business.industry
Drug discovery
Computer science
Cell Culture Techniques
Biomedical Engineering
Cell lineage
Cell fate determination
Regenerative Medicine
Regenerative medicine
Biotechnology
Humans
business
Induced pluripotent stem cell
Neuroscience
Tissue homeostasis
Cell Proliferation
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 1746076X and 17460751
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Regenerative Medicine
- Accession number :
- edsair.doi.dedup.....74f9885f3837ed653409581ff36c41e6