Back to Search
Start Over
LMP1 expression in bone marrow trephines of patients with multiple myeloma confers a survival advantage
- Source :
- Leukemia & Lymphoma. 60:1991-2001
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Multiple myeloma (MM) is a heterogeneous disease of the bone marrow (BM). Its association with Epstein-Barr virus (EBV) remains enigmatic. Aim of our study was to determine expression of latent membrane protein 1 (LMP1), aldehyde dehydrogenase 1 (ALDH1), CD117 and their association with 5-year survival in MM patients. Seven percent of cases expressed LMP1 in MM cells with no association with survival. Whereas, LMP1 expression in CD138- non-neoplastic cells was observed in 80% of the cases, conferring a survival advantage of 1.75 years (mean 3.75 ± 0.28, 95% CI 3.19-4.3). LMP1 in CD138- non-neoplastic cells was associated with CD117 expression in MM cells. Combinatorial analysis of LMP1 and CD117 stratified patients into good prognostic group LMP1+/CD117- (mean survival 4.16 ± 0.39 years) and a worst prognostic group; LMP1-/CD117+ (mean survival 1.02 ± 0.29 years). Our study showed that LMP1 expression in CD138- non-neoplastic cells of BM in MM patients confers a survival advantage.
- Subjects :
- Adult
Male
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Cancer Research
Bone Marrow Cells
Disease
Stem cell marker
Virus
Viral Matrix Proteins
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Biomarkers, Tumor
Humans
Medicine
Survival advantage
Multiple myeloma
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
business.industry
Hematology
Middle Aged
Cell Transformation, Viral
Prognosis
medicine.disease
Immunohistochemistry
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
embryonic structures
Cancer research
Female
Bone marrow
Multiple Myeloma
business
Biomarkers
030215 immunology
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....74f80e7321d8fb24b9db335631a27048