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Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells
- Source :
- Oncotarget
- Publication Year :
- 2017
-
Abstract
- Long noncoding RNAs (LncRNAs) play important roles in tumor development and progression. The expression of lncRNAs is frequently dysregulated in human cancer. DANCR (anti-differentiation noncoding RNA) is a newly identified lncRNA in human cancer, however, its functional roles and clinical value in gastric cancer (GC) remains unknown. In this study, we investigated the expression of DANCR in the tumor tissues and serum of GC patients and analyzed the correlation between DANCR expression levels and the clinicopathological characteristics. Our results showed that the expression of DANCR was higher in the tumor tissues than that in the adjacent non-cancerous tissues. The expression level of DANCR was also elevated in the serum of GC patients compared to that of healthy controls. The expression levels of DANCR were significantly associated with tumor size, TNM stage, lymphatic metastasis and invasion depth. DANCR knockdown inhibited the proliferation of GC cells by inducing cell cycle arrest and cell apoptosis. In addition, DANCR knockdown suppressed gastric cancer growth in vivo. Moreover, DANCR knockdown inhibited the migration and invasion of GC cells via the suppression of epithelial-mesenchymal transition (EMT). However, DANCR overexpression had the opposite effect. DANCR is activated by SALL4 in gastric cancer cells and exerted its oncogenic activities through the activation of β-catenin pathway. Taken together, our findings suggest that DANCR promotes the progression of gastric cancer and have the potential to serve as a novel diagnostic biomarker.
- Subjects :
- 0301 basic medicine
Gene knockdown
Cell cycle checkpoint
SALL4
gastric cancer
Cancer
Biology
medicine.disease
Non-coding RNA
Long non-coding RNA
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
lncRNA
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer cell
Cancer research
medicine
progression
DANCR
Research Paper
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....74f5d02342acdd951b644a3289e4d409