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Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder

Authors :
Yao-Te Tsai
Geng-He Chang
Kam-Fai Lee
Chih-Wei Luan
Cheng-Ming Hsu
Ming-Shao Tsai
Chih-Cheng Chen
Source :
Healthcare, Vol 9, Iss 217, p 217 (2021), Healthcare
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD.

Details

ISSN :
22279032
Volume :
9
Database :
OpenAIRE
Journal :
Healthcare
Accession number :
edsair.doi.dedup.....74ee5129948e0e72ca1a2c091c706ec5
Full Text :
https://doi.org/10.3390/healthcare9020217