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Opportunities and priorities for breast surgical research
- Source :
- Cutress, R, McIntosh, S, Potter, S, Goyal, A, Kirwan, C, Harvey, J, Francis, A, Carmichael, A, Vidya, R, Vaidya, J, Fairbrother, P, Benson, J, Reed, M & the Association of Breast Surgery Surgical Gap Analysis Working Group 2018, ' Opportunities and priorities for breast surgical research ', Lancet Oncology, vol. 19, no. 10, pp. e521-e533 . https://doi.org/10.1016/S1470-2045(18)30511-4, Association of Breast Surgery Surgical Gap Analysis Working Group, Cutress, R I & McIntosh, S A 2018, ' Opportunities and priorities for breast surgical research ', Lancet Oncology, vol. 19, no. 10, pp. e521-e533 . https://doi.org/10.1016/S1470-2045(18)30511-4, Kirwan, C 2018, ' Opportunities and priorities for breast surgical research. ', The Lancet Oncology, vol. 19, no. 10, pp. 521 . https://doi.org/10.1016/S1470-2045(18)30511-4
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- © 2018 Elsevier Ltd The 2013 Breast Cancer Campaign gap analysis established breast cancer research priorities without a specific focus on surgical research or the role of surgeons on breast cancer research. This Review aims to identify opportunities and priorities for research in breast surgery to complement the 2013 gap analysis. To identify these goals, research-active breast surgeons met and identified areas for breast surgery research that mapped to the patient pathway. Areas included diagnosis, neoadjuvant treatment, surgery, adjuvant therapy, and attention to special groups (eg, those receiving risk-reducing surgery). Section leads were identified based on research interests, with invited input from experts in specific areas, supported by consultation with members of the Association of Breast Surgery and Independent Cancer Patients' Voice groups. The document was iteratively modified until participants were satisfied that key priorities for surgical research were clear. Key research gaps included issues surrounding overdiagnosis and treatment; optimising treatment options and their selection for neoadjuvant therapies and subsequent surgery; reducing rates of re-operations for breast-conserving surgery; generating evidence for clinical effectiveness and cost-effectiveness of breast reconstruction, and mechanisms for assessing novel interventions; establishing optimal axillary management, especially post-neoadjuvant treatment; and defining and standardising indications for risk-reducing surgery. We propose strategies for resolving these knowledge gaps. Surgeons are ideally placed for a central role in breast cancer research and should foster a culture of engagement and participation in research to benefit patients and health-care systems. Development of infrastructure and surgical research capacity, together with appropriate allocation of research funding, is needed to successfully address the key clinical and translational research gaps that are highlighted in this Review within the next two decades.
- Subjects :
- medicine.medical_treatment
Psychological intervention
030230 surgery
Medical Oncology
Translational Research, Biomedical
surgery
0302 clinical medicine
Breast cancer
Medicine
Formerly Health & Social Sciences
Overdiagnosis
Neoplasm Metastasis
skin and connective tissue diseases
Neoadjuvant therapy
Mastectomy
Manchester Cancer Research Centre
surgical research
Neoadjuvant Therapy
Treatment Outcome
Oncology
Centre for Surgical Research
030220 oncology & carcinogenesis
Female
Breast reconstruction
medicine.medical_specialty
Breast surgery
review
Translational research
Breast Neoplasms
03 medical and health sciences
SDG 3 - Good Health and Well-being
Research Support as Topic
Adjuvant therapy
Humans
Physician's Role
Surgeons
business.industry
ResearchInstitutes_Networks_Beacons/mcrc
Research
Centre for Appearance Research
visible difference, body image
medicine.disease
Family medicine
Diffusion of Innovation
business
gap analysis
Forecasting
Subjects
Details
- Language :
- English
- ISSN :
- 14702045 and 14745488
- Database :
- OpenAIRE
- Journal :
- Cutress, R, McIntosh, S, Potter, S, Goyal, A, Kirwan, C, Harvey, J, Francis, A, Carmichael, A, Vidya, R, Vaidya, J, Fairbrother, P, Benson, J, Reed, M & the Association of Breast Surgery Surgical Gap Analysis Working Group 2018, ' Opportunities and priorities for breast surgical research ', Lancet Oncology, vol. 19, no. 10, pp. e521-e533 . https://doi.org/10.1016/S1470-2045(18)30511-4, Association of Breast Surgery Surgical Gap Analysis Working Group, Cutress, R I & McIntosh, S A 2018, ' Opportunities and priorities for breast surgical research ', Lancet Oncology, vol. 19, no. 10, pp. e521-e533 . https://doi.org/10.1016/S1470-2045(18)30511-4, Kirwan, C 2018, ' Opportunities and priorities for breast surgical research. ', The Lancet Oncology, vol. 19, no. 10, pp. 521 . https://doi.org/10.1016/S1470-2045(18)30511-4
- Accession number :
- edsair.doi.dedup.....74e7abd14df5231240a1f5acc67c526f