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Responsible use of organoids in precision medicine: the need for active participant involvement
- Source :
- Development
- Publication Year :
- 2020
-
Abstract
- Organoids are three-dimensional multicellular structures grown in vitro from stem cells and which recapitulate some organ function. They are derivatives of living tissue that can be stored in biobanks for a multitude of research purposes. Biobank research on organoids derived from patients is highly promising for precision medicine, which aims to target treatment to individual patients. The dominant approach for protecting the interests of biobank participants emphasizes broad consent in combination with privacy protection and ex ante (predictive) ethics review. In this paradigm, participants are positioned as passive donors; however, organoid biobanking for precision medicine purposes raises challenges that we believe cannot be adequately addressed without more ongoing involvement of patient-participants. In this Spotlight, we argue why a shift from passive donation towards more active involvement is particularly crucial for biobank research on organoids aimed at precision medicine, and suggest some approaches appropriate to this context.
- Subjects :
- Active involvement
Organ function
Context (language use)
Biology
0603 philosophy, ethics and religion
Tissue Culture Techniques
03 medical and health sciences
Directed Tissue Donation
Organoid
Humans
Precision Medicine
Molecular Biology
Biological Specimen Banks
030304 developmental biology
Health Services Needs and Demand
0303 health sciences
Privacy protection
Community Participation
06 humanities and the arts
Precision medicine
Biobank
3. Good health
Organoids
Donation
Engineering ethics
060301 applied ethics
Developmental Biology
Subjects
Details
- ISSN :
- 09501991
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....74e79d30817f47c6800b4cbe48584351
- Full Text :
- https://doi.org/10.1242/dev.177972