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Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension
- Source :
- The American Journal of Cardiology. 56:H101-H104
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- The blood pressure-lowering effects of a calcium-entry blocker, diltiazem (240 or 360 mg/day), and a thiazide diuretic, hydrochlorothiazide (50 or 100 mg/day), were studied in 20 black hypertensive patients. Supine blood pressure decreases of -34/-18 mm Hg for diltiazem and -29/-21 mm Hg for hydrochlorothiazide were noted after 14 weeks of therapy. Differences between drugs were not significant. Blood pressures were normalized in all 4 of the monotherapy nonresponders when the 2 drugs were combined. Significant adverse effects were not noted. These data suggest that diltiazem is an effective antihypertensive agent in black patients. As monotherapy, its blood pressure-lowering effect is equivalent to hydrochlorothiazide.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Supine position
Thiazide diuretic
Blood Pressure
Diltiazem
Electrocardiography
Random Allocation
Pharmacotherapy
Hydrochlorothiazide
Double-Blind Method
Internal medicine
medicine
Humans
Adverse effect
Aged
business.industry
Follow up studies
Benzazepines
Middle Aged
Black or African American
Blood pressure
Delayed-Action Preparations
Hypertension
Cardiology
Drug Therapy, Combination
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....74d8175a070710940f42de361c907f04