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Autoimmunity in atherosclerosis: lessons from experimental models
- Source :
- Lupus. 9:223-227
- Publication Year :
- 2000
- Publisher :
- SAGE Publications, 2000.
-
Abstract
- The modern view of atherosclerosis is of a chronic inflammatory disorder. In accord with this paradigm, the process of uninhibited influx of fat to the vessel wall results from an ‘adequate’ response to various forms of injury (i.e. turbulence, infections, modified lipoproteins). This idea has been further extended by several groups, to assume that the atherosclerotic lesion can be the target of an autoimmune mediated attack. According to this hypothesis, the site of initiation of the plaque should bear/express the target autoantigen, whereas concomitantly a respective immune response is generated in the periphery. The examples illuminating this notion are β2GPI as a target autoantigen, HSP60/65 an oxidized-LDL. Herein we present evidence to support the involvement of autoimmune mechanisms in atherogenesis based on the experience from experimental models and human studies.
- Subjects :
- Chaperonins
Arteriosclerosis
Autoimmunity
Inflammation
030204 cardiovascular system & hematology
medicine.disease_cause
Autoantigens
Lesion
03 medical and health sciences
0302 clinical medicine
Immune system
Bacterial Proteins
Rheumatology
medicine
Animals
Humans
Lupus Erythematosus, Systemic
Beta 2-Glycoprotein I
Glycoproteins
030203 arthritis & rheumatology
Human studies
business.industry
Chaperonin 60
medicine.disease
Lipoproteins, LDL
Disease Models, Animal
beta 2-Glycoprotein I
Immunology
Antibodies, Antiphospholipid
HSP60
medicine.symptom
business
Subjects
Details
- ISSN :
- 14770962 and 09612033
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Lupus
- Accession number :
- edsair.doi.dedup.....74b7072ebe9243d13748c96f8e5281b6