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Myocarditis in systemic lupus erythematosus diagnosed by 18F-fluorodeoxyglucose positron emission tomography
- Source :
- Lupus Science & Medicine
- Publication Year :
- 2018
- Publisher :
- BMJ Publishing Group, 2018.
-
Abstract
- Objectives Cardiovascular diseaseand heart failure (CHF) are leading causes of death in systemic lupus erythematosus (SLE). The underlying mechanisms for increased CHF in SLE are unclear but myocardial inflammation and lupus myocarditis (LM) may play a role. We propose that 18F-fluorodeoxyglucose–positron emission tomography (18F-FDG–PET)/CT can help diagnose LM. Methods This report describes eight patients with presumed LM; five patients were evaluated due to active cardiorespiratory symptoms and three patients were participating in a pilot study to determine the prevalence of subclinical myocarditis in SLE. Clinical characteristics, laboratory and cardiac testing including electrocardiography (ECG), transthoracic echocardiogram (TTE), coronary artery evaluation as well as 18F-FDG–PET/CT imaging are discussed. Results Four patients were African American and the others were Hispanic. Half presented with chest pain; 37% had dyspnoea and 25% were asymptomatic. The median SLE Disease Activity Index (SLEDAI-2K) was 5 (2–18) and SLICC Damage Index (SDI) 0.5 (0–5). The median troponin level was 0.08 ng/mL (0–0.9). The most common ECG findings were non-specific ST-T wave abnormalities (n=5). Fifty per cent of the patients had a decreased ejection fraction on TTE and all patients had diffuse myocardial FDG uptake on 18F-FDG–PET/CT consistent with myocardial inflammation. Conclusion This case series is the first to describe the use of 18F-FDG–PET/CT in the diagnosis of LM and discuss the clinical characteristics and cardiac findings of eight patients with LM supporting the role for cardiac 18F-FDG–PET/CT in its diagnosis.
- Subjects :
- medicine.medical_specialty
Myocarditis
Immunology
030204 cardiovascular system & hematology
Chest pain
Asymptomatic
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
030203 arthritis & rheumatology
Co-Morbidities
Systemic lupus erythematosus
medicine.diagnostic_test
biology
business.industry
General Medicine
medicine.disease
Troponin
Heart failure
Cardiology
biology.protein
Transthoracic echocardiogram
medicine.symptom
business
Electrocardiography
Subjects
Details
- Language :
- English
- ISSN :
- 20538790
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lupus Science & Medicine
- Accession number :
- edsair.doi.dedup.....74aebbe87691b27dc93f62d50f957cb9