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A Territorywide Prevalence Study on Blood-Borne and Enteric Viral Hepatitis in Hong Kong
- Source :
- The Journal of infectious diseases. 219(12)
- Publication Year :
- 2018
-
Abstract
- Background Viral hepatitis epidemiological data are important for the World Health Organization plan of eliminating viral hepatitis. We aimed to document the prevalence of viral hepatitis A to E in Hong Kong. Methods This community-based study was open to all Hong Kong Chinese citizens aged ≥18 years. Baseline data and risk factors were collected. Hepatitis A-E serology was measured, including hepatitis B e antigen, antibodies to hepatitis B e antigen, antibodies to hepatitis D, hepatitis B virus (HBV) DNA for hepatitis B surface antigen (HBsAg)-positive participants, and antibodies to hepatitis B surface antigen and antibodies to hepatitis B core antigen (anti-HBc) in HBsAg-negative participants. Hepatitis C virus (HCV) RNA and genotypes were determined in anti-HCV-positive participants. Results A total of 10 256 participants were recruited from February 2015 to July 2016. Overall HBsAg seroprevalence was 7.8% (95% confidence interval [CI], 7.3%-8.3%), which was reduced significantly with HBV vaccination (odds ratio, 0.15 [95% CI, .11-.21]). Among HBsAg-negative participants, anti-HBc seroprevalence increased from 5.4% ( 65 years). No hepatitis D virus (HDV) cases were detected. Anti-HCV positivity was 0.5% (95% CI, .3%-.6%). Prevalence of antibodies to hepatitis A virus (anti-HAV) and hepatitis E virus (anti-HEV) was 65.2% (95% CI, 64.2%-66.1%) and 33.3% (95% CI, 32.4%-34.2%), respectively, and were influenced by age, family income, and being born in mainland China. Conclusions HBV seroprevalence remained high despite universal vaccination. High anti-HBc seroprevalence underlines the potential issue of HBV reactivation during profound immunosuppression. HCV and HDV remained uncommon. Anti-HAV seroprevalence had decreased whereas anti-HEV seroprevalence had risen.
- Subjects :
- 0301 basic medicine
Adult
Male
HBsAg
Hepatitis, Viral, Human
viruses
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Hepatitis E virus
Risk Factors
Seroepidemiologic Studies
Hepatitis Viruses
medicine
Prevalence
Immunology and Allergy
Humans
030212 general & internal medicine
Hepatitis Antibodies
Aged
Hepatitis
Hepatitis B virus
business.industry
Hepatitis Antigens
virus diseases
Hepatitis A
Middle Aged
medicine.disease
Hepatitis D
Virology
digestive system diseases
030104 developmental biology
Infectious Diseases
Hong Kong
Female
Hepatitis D virus
Viral hepatitis
business
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 219
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....74a656844253bd54a2de651899216f5d