Back to Search
Start Over
Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens
- Source :
- International Journal of Hyperthermia, Vol 36, Iss 1, Pp 937-951 (2019)
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Purpose: The temporal and spatial formation of the temperature field and its changes during/upon water-filtered infrared-A (wIRA)-irradiation in porcine skin and subcutis were investigated in vivo in order to get a detailed physical basis for thermotherapy of superficial tumors and infections caused by thermosensitive microbial pathogens (e.g., Mycobacterium ulcerans causing Buruli ulcer). Methods: Local wIRA-hyperthermia was performed in 11 anesthetized piglets using 85.0 mW cm−2, 103.2 mW cm−2 and 126.5 mW cm−2, respectively. Invasive temperature measurements were carried out simultaneously in 1-min intervals using eight fiber-optical probes at different tissue depths between 2 and 20 mm, and by an IR thermometer at the skin surface. Results: Tissue temperature distribution depended on incident irradiance, exposure time, tissue depths and individual ‘physiologies’ of the animals. Temperature maxima were found at depths between 4 and 7 mm, exceeding skin surface temperatures by about 1–2 K. Tissue temperatures above 37 °C, necessary to eradicate M. ulcerans at depths Conclusions: wIRA-hyperthermia may be considered as a novel therapeutic option for treatment of local skin infections caused by thermosensitive pathogens (e.g., in Buruli ulcer). To ensure temperatures required for heat treatment of superficial tumors deeper than 4 mm, the incident irradiance needed can be controlled either by (a) invasive temperature measurements or (b) control of skin surface temperature and considering possible temperature increases up to 1–2 K in underlying tissue.
- Subjects :
- Hyperthermia
Buruli ulcer
Cancer Research
Pathology
medicine.medical_specialty
lcsh:Medical technology
Fever
Swine
Physiology
hyperthermia of superficial tumors
water-filtered infrared-a (wira-) hyperthermia
superficial hyperthermia
) hyperthermia
Skin infection
A (wIRA
Temperature measurement
030218 nuclear medicine & medical imaging
heat treatment of thermosensitive pathogens
03 medical and health sciences
2737 Physiology (medical)
filtered infrared
0302 clinical medicine
In vivo
Neoplasms
Physiology (medical)
Skin surface
medicine
Animals
Humans
1306 Cancer Research
Skin
invasive temperature measurement
Tissue temperature
630 Agriculture
biology
Chemistry
Water
1314 Physiology
Hyperthermia, Induced
medicine.disease
biology.organism_classification
10187 Department of Farm Animals
lcsh:R855-855.5
030220 oncology & carcinogenesis
Mycobacterium ulcerans
11404 Department of Clinical Diagnostics and Services
570 Life sciences
Subjects
Details
- ISSN :
- 14645157 and 02656736
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- International Journal of Hyperthermia
- Accession number :
- edsair.doi.dedup.....745ce4adf23e96a1600267105e8b6234