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Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
- Source :
- Arthritis care & research, vol 70, iss 10, Hanly, J G, Li, Q, Su, L, Urowitz, M B, Gordon, C, Bae, S C, Romero-Diaz, J, Sanchez-Guerrero, J, Bernatsky, S, Clarke, A E, Wallace, D J, Isenberg, D A, Rahman, A, Merrill, J T, Fortin, P, Gladman, D D, Bruce, I N, Petri, M, Ginzler, E M, Dooley, M A, Steinsson, K, Ramsey-Goldman, R, Zoma, A A, Manzi, S, Nived, O, Jonsen, A, Khamashta, M A, Alarcón, G S, Chatham, W, van Vollenhoven, R F, Aranow, C, Mackay, M, Ruiz-Irastorza, G, Ramos-Casals, M, Lim, S S, Inanc, M, Kalunian, K C, Jacobsen, S, Peschken, C A, Kamen, D L, Askanase, A, Theriault, C & Farewell, V 2018, ' Cerebrovascular Events in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study ', Arthritis Care and Research, vol. 70, no. 10, pp. 1478-1487 . https://doi.org/10.1002/acr.23509
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- OBJECTIVE: To determine the frequency, associations and outcomes of cerebrovascular events (CerVEs) in a multi-ethnic/racial, prospective, SLE disease inception cohort. METHODS: Patients were assessed annually for 19 neuropsychiatric (NP) events including 5 types of CerVEs: (i) Stroke; (ii) Transient ischemia; (iii) Chronic multifocal ischemia; (iv) Subarachnoid/intracranial hemorrhage; (v) Sinus thrombosis. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 scores were collected. Time to event, linear and logistic regressions and multi-state models were used as appropriate. RESULTS: Of 1,826 SLE patients, 88.8% were female, 48.8% Caucasian, mean±SD age 35.1±13.3 years, disease duration 5.6±4.2 months and follow-up 6.6±4.1 years. CerVEs were the fourth most frequent NP event: 82/1,826 (4.5%) patients had 109 events, 103/109 (94.5%) were attributed to SLE and 44/109 (40.4%) were identified at enrollment. The predominant events were stroke [60/109 (55.0%)] and transient ischemia [28/109 (25.7%)]. CerVEs were associated with other NP events attributed to SLE (HR (95% CI): (3.16; 1.73-5.75) (p
- Subjects :
- Adult
Male
medicine.medical_specialty
ResearchInstitutes_Networks_Beacons/MICRA
Lydia Becker Institute
Clinical Sciences
Lupus
Autoimmune Disease
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
Rheumatology
Quality of life
Clinical Research
ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation
Internal medicine
medicine
Lupus Erythematosus, Systemic
Humans
Psychology
Prospective Studies
Young adult
skin and connective tissue diseases
Prospective cohort study
Stroke
030203 arthritis & rheumatology
Lupus anticoagulant
Systemic lupus erythematosus
Lupus erythematosus
Lupus Erythematosus
business.industry
Inflammatory and immune system
Systemic
Evaluation of treatments and therapeutic interventions
Hematology
Middle Aged
medicine.disease
3. Good health
Cerebrovascular Disorders
Manchester Institute for Collaborative Research on Ageing
6.1 Pharmaceuticals
Quality of Life
Public Health and Health Services
Female
Outcomes research
business
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Arthritis care & research, vol 70, iss 10, Hanly, J G, Li, Q, Su, L, Urowitz, M B, Gordon, C, Bae, S C, Romero-Diaz, J, Sanchez-Guerrero, J, Bernatsky, S, Clarke, A E, Wallace, D J, Isenberg, D A, Rahman, A, Merrill, J T, Fortin, P, Gladman, D D, Bruce, I N, Petri, M, Ginzler, E M, Dooley, M A, Steinsson, K, Ramsey-Goldman, R, Zoma, A A, Manzi, S, Nived, O, Jonsen, A, Khamashta, M A, Alarcón, G S, Chatham, W, van Vollenhoven, R F, Aranow, C, Mackay, M, Ruiz-Irastorza, G, Ramos-Casals, M, Lim, S S, Inanc, M, Kalunian, K C, Jacobsen, S, Peschken, C A, Kamen, D L, Askanase, A, Theriault, C & Farewell, V 2018, ' Cerebrovascular Events in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study ', Arthritis Care and Research, vol. 70, no. 10, pp. 1478-1487 . https://doi.org/10.1002/acr.23509
- Accession number :
- edsair.doi.dedup.....744ff6fb39f48103329aa1117313890e