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Variation in the Level of Thyroid Markers in Association with Inflammation in Patients with Type 2 Diabetes
- Source :
- Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:924-929
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Background: A possible relationship between thyroid hormones and glucose metabolism in diabetes has already been established. Objectives: We aimed to evaluate the thyroid function markers and their relationship with inflammation, which is considered as a pathogenic condition of diabetes. Methods: This cross-sectional study included 276 patients with type 2 diabetes. Serum levels of thyroid (TSH, FT4, and FT3) and inflammatory markers (CRP, IL-6, and TNF-α) were measured. Results: The mean age of the subjects was 55.2 years and mean diabetes duration of 16.8 years. The inflammatory markers showed significant differences with the tertiles of TSH and thyroid hormones. TSH was significantly correlated with inflammatory markers, IL-6 (r = 0.13, P = 0.020) and TNF-α (r = 0.17, P = 0.003), while FT4 had a correlation only with TNF-α (r = 0.25, P = Conclusion: Abnormalities in the thyroid hormone metabolism are related to the increased inflammatory activity as well as insulin resistance, and are associated with the disorders of glucose metabolism.
- Subjects :
- Adult
Blood Glucose
Male
Thyroid Hormones
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Saudi Arabia
Thyroid Gland
Thyrotropin
Blood Pressure
Inflammation
Type 2 diabetes
Thyroid Function Tests
Carbohydrate metabolism
Body Mass Index
Insulin resistance
Internal medicine
Diabetes mellitus
medicine
Humans
Immunology and Allergy
Aged
business.industry
Thyroid
Middle Aged
medicine.disease
Cross-Sectional Studies
Endocrinology
medicine.anatomical_structure
Diabetes Mellitus, Type 2
Thyroid hormones
Female
Insulin Resistance
medicine.symptom
Thyroid function
business
Biomarkers
Subjects
Details
- ISSN :
- 18715303
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Endocrine, Metabolic & Immune Disorders - Drug Targets
- Accession number :
- edsair.doi.dedup.....744e887f471545bf9f7ea9ad0547512a