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A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus

Authors :
G. Trottier
Judy Greig
Barbara Wilhelm
L. N. Borden
Alain Houde
Andrijana Rajić
Janet Harris
Lisa Waddell
C. Price
Source :
Epidemiology and Infection. 139:1127-1144
Publication Year :
2011
Publisher :
Cambridge University Press (CUP), 2011.

Abstract

SUMMARYThe objectives of our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association between human exposure to swine/pork and HEV infection quantitatively using systematic review/meta-analysis methodology. From 1890 initially identified abstracts, 327 were considered for the review. Five study design types (cross-sectional, prevalence, genotyping, case-report and experimental transmission studies) were identified. A significant association between occupational exposure to swine and human HEV IgG seropositivity was reported in 10/13 cross-sectional studies. The association reported between pork consumption and HEV IgG seropositivity was inconsistent. The quantification of viral load in swine and retail pork, viral load required for infection in primates, cohort and case-control studies in humans, and formal risk assessment are recommended before specific public-health policy actions are taken.

Details

ISSN :
14694409 and 09502688
Volume :
139
Database :
OpenAIRE
Journal :
Epidemiology and Infection
Accession number :
edsair.doi.dedup.....74397da9bfb6a1b318e03e06be98bd0b
Full Text :
https://doi.org/10.1017/s0950268811000677