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A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus
- Source :
- Epidemiology and Infection. 139:1127-1144
- Publication Year :
- 2011
- Publisher :
- Cambridge University Press (CUP), 2011.
-
Abstract
- SUMMARYThe objectives of our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association between human exposure to swine/pork and HEV infection quantitatively using systematic review/meta-analysis methodology. From 1890 initially identified abstracts, 327 were considered for the review. Five study design types (cross-sectional, prevalence, genotyping, case-report and experimental transmission studies) were identified. A significant association between occupational exposure to swine and human HEV IgG seropositivity was reported in 10/13 cross-sectional studies. The association reported between pork consumption and HEV IgG seropositivity was inconsistent. The quantification of viral load in swine and retail pork, viral load required for infection in primates, cohort and case-control studies in humans, and formal risk assessment are recommended before specific public-health policy actions are taken.
- Subjects :
- medicine.medical_specialty
Biomedical Research
Meat
Swine
Epidemiology
medicine.disease_cause
Hepatitis E virus
Occupational Exposure
Zoonoses
medicine
Animals
Humans
Genotyping
Swine Diseases
biology
business.industry
Zoonosis
Viral Load
biology.organism_classification
medicine.disease
Hepatitis E
Virology
Caliciviridae
Infectious Diseases
Meta-analysis
business
Viral load
Subjects
Details
- ISSN :
- 14694409 and 09502688
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Infection
- Accession number :
- edsair.doi.dedup.....74397da9bfb6a1b318e03e06be98bd0b
- Full Text :
- https://doi.org/10.1017/s0950268811000677