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Hyperuricemia is a risk factor for the progression to end-stage renal disease in minimal change disease
- Source :
- Kidney Research and Clinical Practice, Kidney Research and Clinical Practice, Vol 40, Iss 3, Pp 411-418 (2021)
- Publication Year :
- 2021
- Publisher :
- The Korean Society of Nephrology, 2021.
-
Abstract
- BACKGROUND Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD. METHODS A total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relationship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival analysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation. RESULTS A total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve, serum uric acid levels exhibited a positive correlation with ESRD progression in patients with MCD. In the fully adjusted model, the risk of MCD progression increased by 29% for every 1 mg/dL increase in the baseline serum uric acid level (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.09-1.54; p = 0.004). Falling into the high uric acid group (serum uric acid level > 7 mg/dL in men and > 6 mg/dL in women) was also a risk factor for progression of MCD to ESRD (HR, 3.40; 95% CI, 1.59-7.31; p < 0.001). CONCLUSION Our study shows that hyperuricemia is an independent risk factor for the progression to ESRD in patients with MCD.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Specialties of internal medicine
Hyperuricemia
urologic and male genital diseases
Gastroenterology
End stage renal disease
chemistry.chemical_compound
End-stage renal disease
Internal medicine
Chronic kidney disease
medicine
Minimal change disease
Risk factor
Dialysis
Kidney transplantation
business.industry
Hazard ratio
nutritional and metabolic diseases
General Medicine
medicine.disease
RC31-1245
eye diseases
chemistry
RC581-951
Uric acid
Original Article
business
Subjects
Details
- Language :
- English
- ISSN :
- 22119140 and 22119132
- Volume :
- 40
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Kidney Research and Clinical Practice
- Accession number :
- edsair.doi.dedup.....742c4d4c8b7917f405c38eab37aacd05