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A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth
- Source :
- NPJ systems biology and applications, vol 9, iss 1
- Publication Year :
- 2023
- Publisher :
- Springer Science and Business Media LLC, 2023.
-
Abstract
- The exact mechanism controlling cell growth remains a grand challenge in developmental biology and regenerative medicine. The Drosophila wing disc tissue serves as an ideal biological model to study mechanisms involved in growth regulation. Most existing computational models for studying tissue growth focus specifically on either chemical signals or mechanical forces. Here we developed a multiscale chemical-mechanical model to investigate the growth regulation mechanism based on the dynamics of a morphogen gradient. By comparing the spatial distribution of dividing cells and the overall tissue shape obtained in model simulations with experimental data of the wing disc, it is shown that the size of the domain of the Dpp morphogen is critical in determining tissue size and shape. A larger tissue size with a faster growth rate and more symmetric shape can be achieved if the Dpp gradient spreads in a larger domain. Together with Dpp absorbance at the peripheral zone, the feedback regulation that downregulates Dpp receptors on the cell membrane allows for further spreading of the morphogen away from its source region, resulting in prolonged tissue growth at a more spatially homogeneous growth rate.
- Subjects :
- Animal
1.1 Normal biological development and functioning
Applied Mathematics
Bioengineering
Biological
Regenerative Medicine
General Biochemistry, Genetics and Molecular Biology
Computer Science Applications
Models
Underpinning research
Modeling and Simulation
Wings
Drug Discovery
Animals
Drosophila Proteins
Drosophila
Generic health relevance
Cell Proliferation
Subjects
Details
- ISSN :
- 20567189
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- npj Systems Biology and Applications
- Accession number :
- edsair.doi.dedup.....742b25b2c1d705c584ce7b13ec500ecd