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MTRR rs326119 polymorphism is associated with plasma concentrations of homocysteine and cobalamin, but not with congenital heart disease or coronary atherosclerosis in Brazilian patients
- Source :
- International Journal of Cardiology: Heart & Vasculature, Vol 14, Iss C, Pp 1-5 (2017), International Journal of Cardiology. Heart & Vasculature, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Background Differences in the distribution of the MTRR rs326119 polymorphism (c.56+781 A>C) between patients with congenital heart disease (CHD) and controls have been described in Chinese individuals. The association is thought to be due to deregulation of homocysteine-cobalamin pathways. This has not been replicated in other populations. The primary objective of this study was to assess the influence of the MTRR rs326119 polymorphism on biochemical parameters of vitamin B12 metabolism, coronary lesions, and congenital heart disease in Brazilian subjects. Methods We selected 722 patients with CHD, 1432 patients who underwent coronary angiography, and 156 blood donors. Genotyping for the MTRR polymorphism was evaluated by high-resolution melting analysis, and biochemical tests of vitamin B12 metabolism were measured. Results Subjects carrying the AC or CC genotypes had higher homocysteine concentrations (9.7±0.4μmol/L and 10.1±0.6μmol/L) and lower cobalamin concentrations (260.5±13.3pmol/L and 275.6±19.9pmol/L) compared with the subjects carrying the AA genotype (8.7±0.5μmol/L and 304.8±14.7pmol/L), respectively. A multiple linear regression model also identified a significant association between the number of C variant alleles with the concentrations of homocysteine and cobalamin. Nonetheless, the allelic and genotypic distributions for MTRR rs326119 were not associated with CHD or coronary atherosclerosis in the studied samples. Conclusion Our findings indicate that the MTRR rs326119 variant might be a genetic marker associated with homocysteine and cobalamin concentrations, but not a strong risk factor for CHD or coronary atherosclerosis in the Brazilian population.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Heart disease
Homocysteine
rs326119
030204 cardiovascular system & hematology
Gastroenterology
Cobalamin
Article
MTRR gene
DOENÇAS CONGÊNITAS
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Genotype
medicine
Vitamin B12
Genotyping
Coronary atherosclerosis
Congenital heart disease
Genetics
business.industry
medicine.disease
MTRR
030104 developmental biology
chemistry
lcsh:RC666-701
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 23529067
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology: Heart & Vasculature
- Accession number :
- edsair.doi.dedup.....7422eeef035b6d42a5a7838771f8b9ca