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Oxidative stress and autonomic nerve function in early type 1 diabetes
- Source :
- Clinical Autonomic Research. 21:19-28
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- The biochemical mechanisms by which hyperglycemia causes microvascular disease and neuropathy are poorly understood. Experimental studies have established that oxidative stress is present in diabetic rodents with neuropathy, and that antioxidant therapy is protective. Oxidative stress is also present in human diabetes, but its clinical importance is uncertain. We examined several biochemical measures of oxidative stress in 37 patients with recent-onset (less than 2 years) type 1 diabetes annually in a 3-year longitudinal study. We also performed a comprehensive annual evaluation of somatosensory and autonomic nerve function. A total of 41 control subjects were studied. Malondialdehyde excretion, a measure of lipid peroxidation, was 1.5l ± .1 μmol/g creatinine in the control subjects, but 2.43 ± . 3 in the diabetic patients in year one, 2.39 ± .2 in year two and 1.92 ± .15 in year three, which was different from controls across all years; p
- Subjects :
- Male
medicine.medical_specialty
Urinary system
Sweating
Autonomic Nervous System
medicine.disease_cause
Antioxidants
chemistry.chemical_compound
Diabetic Neuropathies
Diabetes mellitus
Internal medicine
Humans
Medicine
Longitudinal Studies
Sex Characteristics
Creatinine
Type 1 diabetes
Autonomic nerve
Endocrine and Autonomic Systems
business.industry
medicine.disease
Malondialdehyde
Reactive Nitrogen Species
Sudomotor
Oxidative Stress
Diabetes Mellitus, Type 1
Endocrinology
Autonomic Nervous System Diseases
chemistry
Female
Lipid Peroxidation
Neurology (clinical)
business
Oxidative stress
Subjects
Details
- ISSN :
- 16191560 and 09599851
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical Autonomic Research
- Accession number :
- edsair.doi.dedup.....7422aeef38858910b85de5f4b0be0e1f