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Imprinting, immunodominance, and other impediments to generating broad influenza immunity
- Source :
- Immunological Reviews. 296:191-204
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Natural influenza virus infections and seasonal vaccinations often do not confer broadly neutralizing immunity across diverse influenza strains. In addition, the virus is capable of rapid antigenic drift in order to evade pre-existing immunity. The surface glycoproteins, hemagglutinin, and neuraminidase can easily mutate their immunodominant epitopes without impacting fitness. Skewing human antibody repertoires to target more conserved epitopes is thus an expanding area of research: Many groups are attempting to produce universal influenza vaccines that can protect across a wide variety of strains. Achieving this goal will require a detailed understanding of how infection history impacts humoral responses. It will also require the ability to manipulate or enhance B cell selection in order to expand clones that can recognize subdominant but protective epitopes. In this review, we will discuss what immune imprinting means to immunologists and describe efforts to overcome or silence imprinting in order to improve vaccination efficiency.
- Subjects :
- 0301 basic medicine
Subdominant
Immunology
Immunodominance
Computational biology
Epitope
Antigenic drift
Virus
03 medical and health sciences
0302 clinical medicine
Influenza, Human
Animals
Humans
Immunology and Allergy
Clonal Selection, Antigen-Mediated
Original antigenic sin
Antigens, Viral
Immunity, Cellular
biology
Immunodominant Epitopes
Vaccination
Orthomyxoviridae
Immunity, Humoral
030104 developmental biology
Influenza Vaccines
Host-Pathogen Interactions
biology.protein
Neuraminidase
030215 immunology
Subjects
Details
- ISSN :
- 1600065X and 01052896
- Volume :
- 296
- Database :
- OpenAIRE
- Journal :
- Immunological Reviews
- Accession number :
- edsair.doi.dedup.....7412fec0392ad75f4149a66f4341bf93