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Pulmonary hypertension in patients with Philadelphia-negative myeloproliferative neoplasms: a single-center retrospective analysis of 225 patients
- Source :
- Blood research
- Publication Year :
- 2020
- Publisher :
- The Korean Society of Hematology, 2020.
-
Abstract
- Background The prevalence of pulmonary hypertension (PH) in myeloproliferative neoplasms (MPNs) varies among studies. We analyzed the prevalence of PH in Korean patients with Philadelphia-negative (Ph-) MPNs. Methods Medical records of patients with Ph- MPNs [essential thrombocythemia (ET), polycythemia vera (PV), or primary myelofibrosis (PMF)] visiting a single hospital between 1993 and 2019 were reviewed retrospectively. Transthoracic echocardiographic examination (TTE) results were reviewed and PH was diagnosed according to established guidelines. Results Of the 320 MPN (179 ET, 107 PV, and 34 PMF) patients, 225 (121 ET, 83 PV, and 21 PMF) underwent TTE. Of these 225 MPN patients, 19 of 121 (15.7%) ET, 9 of 83 (10.8%) PV, and 6 of 21 (28.6%) PMF patients had PH. PV patients with PH were older [71 (42‒85) vs. 61.5 (26‒91) yr, respectively; P =0.049], predominantly female (male:female ratio, 0.29 vs. 1.96, respectively; P =0.010), had lower hemoglobin levels (15.9±2.6 g/dL vs. 18.4±2.6 g/dL, respectively; P =0.010), and higher platelet counts (616.6±284.2×109/L vs. 437.7±191.7×109/L, respectively; P =0.020) than PV patients without PH. PMF patients with PH had higher monocyte counts (1.3±0.5×109/L vs. 0.8±0.4×109/L, respectively; P =0.031) than those without PH. PH was a risk factor for poor survival in PV (HR, 12.4; 95% CI, 1.8‒86.6). Conclusion PH is common in patients with Ph- MPNs and hence, careful screening for PH is warranted.
- Subjects :
- medicine.medical_specialty
Myeloproliferative neoplasm
Single Center
Gastroenterology
Essential thrombocytopenia
Pulmonary hypertension
03 medical and health sciences
0302 clinical medicine
Polycythemia vera
Internal medicine
medicine
In patient
Risk factor
Myelofibrosis
business.industry
Essential thrombocythemia
Hematology
medicine.disease
Primary myelofibrosis
030220 oncology & carcinogenesis
Original Article
business
030215 immunology
Subjects
Details
- ISSN :
- 22880011 and 2287979X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- BLOOD RESEARCH
- Accession number :
- edsair.doi.dedup.....74008eb4d30b7c60bcd82b685587904b