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Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging
- Source :
- Journal of Biomedical Optics, Journal of biomedical optics, vol 24, iss 11
- Publication Year :
- 2019
- Publisher :
- SPIE-Intl Soc Optical Eng, 2019.
-
Abstract
- Author(s): Rowland, Rebecca; Ponticorvo, Adrien; Jarrin Lopez, Alberto; Li, Shiri; Li, Xiaodong; Ichii, Hirohito; Durkin, Anthony | Abstract: Transplantation of kidneys results in delayed graft function in as many as 40% of cases. During the organ transplantation process, donor kidneys undergo a period of cold ischemic time (CIT), where the organ is preserved with a cold storage solution to maintain tissue viability. Some complications observed after grafting may be due to damage sustained to the kidney during CIT. However, the effects due to this damage are not apparent until well after transplant surgery has concluded. To this end, we have used spatial frequency domain imaging (SFDI) to measure spatially resolved optical properties of porcine kidneys over the course of 80-h CIT. During this time, we observed an increase in both reduced scattering (μsa') and absorption (μa) coefficients. The measured scattering b parameter increased until 24nh of CIT, then returned toward baseline during the remaining duration of the imaging sequence. These results show that the optical properties of kidney tissue change with increasing CIT and suggest that continued investigation into the application of SFDI to kidneys under CIT may lead to the development of a noninvasive method for assessing graft viability.
- Subjects :
- Optics and Photonics
Swine
Image Processing
Biopsy
Optical Physics
030230 surgery
Kidney
01 natural sciences
Organ transplantation
Imaging
Scattering
Computer-Assisted
0302 clinical medicine
Image Processing, Computer-Assisted
Scattering, Radiation
cold storage preservation
Radiation
Spatially resolved
Cold Ischemia
Optical Imaging
organ transplantation
Organ Preservation
Domain imaging
Atomic and Molecular Physics, and Optics
Delayed Graft Function
Electronic, Optical and Magnetic Materials
Cold Temperature
medicine.anatomical_structure
Paper
kidney
medicine.medical_specialty
Biomedical Engineering
Ischemia
Color
Cold storage
010309 optics
Biomaterials
03 medical and health sciences
Opthalmology and Optometry
0103 physical sciences
medicine
Animals
tissue optics
business.industry
Optics
medicine.disease
Transplantation
spatial frequency domain imaging
kidney, cold storage preservation
Nuclear medicine
business
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....73f88d9b5374563eca2637c481f602f2