Back to Search
Start Over
Integrative immunologic and genomic characterization of brain metastasis from ovarian/peritoneal cancer
- Source :
- Pathology, research and practice. 215(8)
- Publication Year :
- 2018
-
Abstract
- Brain metastasis from ovarian/peritoneal cancer is a rare disease that has a dismal prognosis. And genomic alterations and immune-profiling in primary ovarian/ peritoneal cancer and brain metastatic tumor tissues have not been fully elucidated. Multiplexed immunofluorescence and whole-exome sequencing of two matched brain metastatic tumor and primary ovarian/peritoneal cancer tissues were performed. The overall density of immune infiltrates in metastatic tissues (brain) was not significantly different from those in primary cancer tissues (case 1 primary: 2.12% and case 1 metastasis: 2.22%; case 2 primary: 1.70%, and case 2 metastasis: 3.46%). Of note, however, PD-L1 expression in the metastases was higher than that in the primary tumors. We found more non-silent mutations, cancer-related genes, loss of heterozygosity (LOH) and longer lengths of copy-number alterations (CNA) in brain metastases compared to primary ovarian/peritoneal cancers. We report immunologic and genomic profiles of primary ovarian/peritoneal cancer with brain metastasis that may not only provide useful information for understanding its pathogenesis, but also clues for further innovative therapeutic treatments for ovarian cancer.
- Subjects :
- 0301 basic medicine
endocrine system diseases
Carcinoma, Ovarian Epithelial
Immunofluorescence
Pathology and Forensic Medicine
Metastasis
Pathogenesis
Loss of heterozygosity
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Humans
Neoplasm Metastasis
Peritoneal Neoplasms
Aged
Ovarian Neoplasms
medicine.diagnostic_test
business.industry
Brain Neoplasms
Ovary
Brain
Cell Biology
Middle Aged
medicine.disease
Prognosis
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Cancer research
Female
Ovarian cancer
business
Rare disease
Brain metastasis
Subjects
Details
- ISSN :
- 16180631
- Volume :
- 215
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Pathology, research and practice
- Accession number :
- edsair.doi.dedup.....73e372d50d8354b3bf95d9d8088bfd3b