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Prostate volume index and prostatic chronic inflammation predicted low tumor load in 945 patients at baseline prostate biopsy
- Publication Year :
- 2020
-
Abstract
- To assess associations of prostate volume index (PVI), defined as the ratio of the volume of the central transition zone to the volume of the peripheral zone of the prostate and prostatic chronic inflammation (PCI) as predictors of tumor load by number of positive cores (PC) in patients undergoing baseline random biopsies. Parameters evaluated included age, PSA, total prostate volume, PSA density, digital rectal exam, PVI, and PCI. All patients underwent standard transperineal random biopsies. Tumor load was evaluated as absent (no PC), limited (1–3 PC), and extensive (more than 3 PC). The association of factors with the risk of tumor load was evaluated by the multinomial logistic regression model. The study evaluated 945 patients. Cancer PC were detected in 477 (507%) cases of whom 207 (43.4%) had limited tumor load and 270 (56.6%) had extensive tumor load. Among other factors, comparing patients with limited tumor load with negative cases, PVI [odds ratio, OR = 0.521, 95% confidence interval (CI) 0.330–0.824; p
- Subjects :
- Male
medicine.medical_specialty
Prostate biopsy
Urology
Biopsy
Prostate tumor grade
Prostate volume index
Prostatic chronic inflammation
Prostate cancer
Prostate
Predictive Value of Tests
medicine
Humans
Tumor volume
Aged
Retrospective Studies
Prostate-specific antigen
medicine.diagnostic_test
business.industry
Cancer
Prostatic Neoplasms
Odds ratio
Organ Size
Middle Aged
medicine.disease
Confidence interval
Prostatitis
Tumor Burden
medicine.anatomical_structure
Conventional PCI
Chronic Disease
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....73ccfb2b96c980c427a2dcd9754d815d