Back to Search
Start Over
Natural Recombinant between Equine Herpesviruses 1 and 4 in the ICP4 Gene
- Source :
- Microbiology and Immunology. 49:167-179
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Equine herpesvirus 1 (EHV-1) is a pathogen causing rhinopneumonia in young horses, abortion in mares, and myeloencephalitis in adult horses. Two types, EHV-1 P and EHV-1 B, have recently been dominant among 16 electropherotypes. EHV-1 P and EHV-1 B viruses were compared by long and accurate polymerase chain reaction (LA-PCR) and restriction fragment length polymorphism (RFLP) analysis. Differences in restriction sites were found to be focused in ORF64, which encodes the infected cell protein 4 (ICP4), and downstream of the ICP4 gene. The 3 ' -end and downstream of ICP4 gene of EHV-1 B were found to be replaced by the corresponding region of EHV-4, indicating that EHV-1 B is a naturally occurring recombinant virus between progenitors of EHV-1 P and EHV-4. This is the first report showing a natural interspecies recombinant in alphaherpesviruses.
- Subjects :
- viruses
Molecular Sequence Data
Immunology
Equine herpesvirus 1
Biology
Recombinant virus
Microbiology
law.invention
Viral Proteins
law
Cricetinae
Virology
Animals
Horses
Gene
Pathogen
Polymerase chain reaction
Recombination, Genetic
Base Sequence
Herpesviridae Infections
biology.organism_classification
Molecular biology
Restriction site
Recombinant DNA
Restriction fragment length polymorphism
Sequence Alignment
Herpesvirus 4, Equid
Herpesvirus 1, Equid
Subjects
Details
- ISSN :
- 03855600
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....73bb9fb6dc721ffc5e3c765a10a66707