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Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development
- Source :
- Organic letters. 21(18)
- Publication Year :
- 2019
-
Abstract
- LaeA is a positive global regulator of secondary metabolism in Ascomycetes, but its role in Basidiomycetes, including medicinal mushrooms, remains uncharacterized. Here, knockout of laeA in the model mushroom Coprinopsis cinerea unexpectedly upregulated the biosynthesis of a novel siderophore, coprinoferrin. Furthermore, knockout of the nonribosomal peptide synthetase-encoding cpf1 responsible for coprinoferrin biosynthesis resulted in growth defect and loss of fruiting body formation, indicating the complex role that this natural product plays in fungal cell development.
- Subjects :
- Siderophore
Siderophores
Secondary metabolite
010402 general chemistry
01 natural sciences
Biochemistry
Microbiology
Ascomycota
Nonribosomal peptide
medicine
Fruiting Bodies, Fungal
Physical and Theoretical Chemistry
Secondary metabolism
chemistry.chemical_classification
Mushroom
biology
Molecular Structure
010405 organic chemistry
Cell growth
fungi
Organic Chemistry
food and beverages
biology.organism_classification
0104 chemical sciences
Coprinopsis cinerea
chemistry
Mushroom hunting
Agaricales
medicine.drug
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 21
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....73b937fa3cfcdd8321d630b8f9e8e061