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Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1
- Source :
- Proceedings of the National Academy of Sciences. 109
- Publication Year :
- 2012
- Publisher :
- Proceedings of the National Academy of Sciences, 2012.
-
Abstract
- The mechanisms that promote an inflammatory environment and accelerated atherosclerosis in diabetes are poorly understood. We show that macrophages isolated from two different mouse models of type 1 diabetes exhibit an inflammatory phenotype. This inflammatory phenotype associates with increased expression of long-chain acyl-CoA synthetase 1 (ACSL1), an enzyme that catalyzes the thioesterification of fatty acids. Monocytes from humans and mice with type 1 diabetes also exhibit increased ACSL1. Furthermore, myeloid-selective deletion of ACSL1 protects monocytes and macrophages from the inflammatory effects of diabetes. Strikingly, myeloid-selective deletion of ACSL1 also prevents accelerated atherosclerosis in diabetic mice without affecting lesions in nondiabetic mice. Our observations indicate that ACSL1 plays a critical role by promoting the inflammatory phenotype of macrophages associated with type 1 diabetes; they also raise the possibilities that diabetic atherosclerosis has an etiology that is, at least in part, distinct from the etiology of nondiabetic vascular disease and that this difference is because of increased monocyte and macrophage ACSL1 expression.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Transgene
Mice, Transgenic
Inflammation
Biology
Models, Biological
Monocytes
Mice
Internal medicine
Diabetes mellitus
Coenzyme A Ligases
Diabetes Mellitus
medicine
Animals
Humans
Macrophage
Receptor
Alleles
Bone Marrow Transplantation
Type 1 diabetes
Multidisciplinary
Macrophages
Monocyte
Atherosclerosis
medicine.disease
Lipids
Phenotype
medicine.anatomical_structure
Endocrinology
Receptors, LDL
Immunology
Female
medicine.symptom
Gene Deletion
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....73b4122685246aef88dfb7300569f44d