Back to Search
Start Over
Pentoxifylline and tocopherol in the management of cancer patients with medication-related osteonecrosis of the jaw: an observational retrospective study of initial case series
- Source :
- Oral surgery, oral medicine, oral pathology and oral radiology. 122(4)
- Publication Year :
- 2016
-
Abstract
- Objective Very few studies have evaluated the efficacy of pentoxifylline and tocopherol (PENT-E) in the management of medication-related osteonecrosis of the jaw (MRONJ), although some studies have shown the therapeutic and prophylactic benefit of PENT-E in the management of osteoradionecrosis. We report the outcomes of MRONJ managed with PENT-E in patients with metastatic bone disease or multiple myeloma. Study Design Seven patients diagnosed with established cases of refractory MRONJ caused by antiresorptive medications for the management of metastatic bone tumors or multiple myeloma were administered PENT-E for a mean period of 16.8 months (range 3-48 months). Results At the latest follow-up visit, all patients demonstrated relief of symptoms. There was radiographic evidence of new bone fill of prior radiolucent defect in all patients. Two patients had resolution of exposed bone, two patients had partial resolution, one patient had no change in exposed bone, and one patient with three sites of exposed bone before starting PENT-E had resolution in one site, partial resolution in another site, and no change in the third site. PENT-E was well tolerated in all patients. Conclusions Our case series demonstrated that PENT-E was well tolerated and may be an effective adjunct in the management of MRONJ.
- Subjects :
- Male
medicine.medical_specialty
Bone disease
Osteoradionecrosis
Tocopherols
Bone Neoplasms
Antioxidants
Article
Pathology and Forensic Medicine
Pentoxifylline
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Dentistry (miscellaneous)
Multiple myeloma
Aged
Retrospective Studies
Bisphosphonate-associated osteonecrosis of the jaw
Bone Density Conservation Agents
business.industry
Retrospective cohort study
030206 dentistry
Free Radical Scavengers
Middle Aged
medicine.disease
Surgery
Treatment Outcome
030220 oncology & carcinogenesis
Bisphosphonate-Associated Osteonecrosis of the Jaw
Female
Oral Surgery
Osteonecrosis of the jaw
business
Multiple Myeloma
medicine.drug
Subjects
Details
- ISSN :
- 22124411
- Volume :
- 122
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oral surgery, oral medicine, oral pathology and oral radiology
- Accession number :
- edsair.doi.dedup.....73a548a907bcefe4b30f587628215ef7