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Hyperuricaemia and accelerated reduction in renal function
- Source :
- Scandinavian Journal of Rheumatology. 40:116-121
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- Hyperuricaemia has been linked to reduced renal function, and evidence indicates that it may be associated with acceleration of the decline in glomerular filtration rate (GFR) and progression of chronic kidney disease (CKD).We analysed a population of subjects who had undergone serum uric acid (SUA) and serum creatinine measurements in a hospital-based cohort. Initial and final serum creatinine measurements were used to calculate the estimated glomerular filtration rate (eGFR) and the annual decline in eGFR. Cox regression was used to investigate the relationship between SUA and CKD progression.A total of 63,785 subjects were enrolled in the study during a 12-year follow-up period. The mean age at the time of initial serum creatinine measurement was 50.0 ± 14.9 years. Hyperuricaemic subjects had a significantly larger annual eGFR decline, both in absolute terms (2.5 ± 9.5 mL/min/1.73 m(2) per year) and as a percentage (2.8 ± 11.6% per year), as compared to the normouricaemia group (1.3 ± 9.6 mL/min/1.73 m(2) per year, 1.1 ± 11.1% per year, p0.001). After adjustment for age, sex, status of diabetes mellitus (DM) and hypertension, baseline eGFR, azotaemia, hypercholesterolaemia, and hyperglycaemia, hyperuricaemia was associated with a hazard ratio (HR) of 1.28 [95% confidence interval (CI) 1.23-1.33, p0.001] for an accelerated eGFR decline ≥ 3 mL/min/1.73 m(2) per year and an HR of 1.52 (95% CI 1.46-1.59) for CKD progression at the end of follow-up.Hyperuricaemia was associated with an accelerated decline in eGFR and higher risk of CKD progression. Therefore, renal function should be monitored closely in patients with hyperuricaemia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Hypercholesterolemia
Immunology
Population
Urology
Renal function
Hyperuricemia
Serum Creatinine Measurement
urologic and male genital diseases
Cohort Studies
chemistry.chemical_compound
Rheumatology
Internal medicine
medicine
Humans
Immunology and Allergy
education
Aged
Retrospective Studies
Creatinine
education.field_of_study
business.industry
General Medicine
Middle Aged
medicine.disease
Uric Acid
Endocrinology
chemistry
Hyperglycemia
Chronic Disease
Cohort
Disease Progression
Regression Analysis
Uric acid
Female
Kidney Diseases
business
Follow-Up Studies
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 15027732 and 03009742
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....73a00aa87a59b4dff42b2580791b82ee