Back to Search
Start Over
Energy Regulation Mechanism and Therapeutic Potential of Asprosin
- Source :
- Diabetes
- Publication Year :
- 2020
- Publisher :
- American Diabetes Association, 2020.
-
Abstract
- Genetic studies of patients with neonatal progeroid syndrome led to the discovery of the novel fasting-induced, glucogenic, and orexigenic hormone named asprosin, the C-terminal cleavage product of profibrillin. Upon secretion, asprosin travels to the liver, where it exerts a glucogenic effect through OR4M1, an olfactory G-protein–coupled receptor. It also crosses the blood-brain barrier to stimulate appetite-modulating neurons in the arcuate nucleus of the hypothalamus, exerting an orexigenic effect via an as yet unidentified receptor. Specifically, it stimulates appetite by activating orexigenic AgRP neurons and inhibiting anorexigenic POMC neurons. Studies have also focused on the therapeutic potential of inhibiting asprosin for treatment of obesity and type 2 diabetes, both of which are characterized by high levels of circulating asprosin. It has been shown that anti-asprosin monoclonal antibodies reduce blood glucose, appetite, and body weight, validating asprosin as a therapeutic target. Current work aims to uncover key features of the asprosin biology such as the identification of its neuronal receptor, identification of the secretion mechanism from adipose tissue, and development of anti-asprosin monoclonal antibodies as diabetes and obesity therapies.
- Subjects :
- Blood Glucose
0301 basic medicine
medicine.medical_specialty
Fibrillin-1
Peptide Hormones
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Adipose tissue
030209 endocrinology & metabolism
Biology
Neonatal Progeroid Syndrome
03 medical and health sciences
0302 clinical medicine
Internal medicine
Orexigenic
Internal Medicine
medicine
Animals
Humans
Secretion
Obesity
Receptor
media_common
Microfilament Proteins
Appetite
Peptide Fragments
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
Hypothalamus
Energy Metabolism
Methodology Review
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....7394761a15d51ee8e2eef32c27010e80