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The Implantable Pediatric Artificial Lung: Interim Report on the Development of an End-Stage Lung Failure Model
- Publication Year :
- 2015
-
Abstract
- An implantable pediatric artificial lung (PAL) may serve as a bridge to lung transplantation for children with end-stage lung failure (ESLF); however, an animal model of pediatric lung failure is needed to evaluate the efficacy of PAL before it can enter clinical trials. The objective of this study was to assess ligation of the right pulmonary artery (rPA) as a model for pediatric ESLF. Seven lambs weighing 20-30 kg underwent rPA ligation and were recovered and monitored for up to 4 days. Intraoperatively, rPA ligation significantly increased physiologic dead space fraction (Vd/Vt; baseline = 48.6 ± 5.7%, rPA ligation = 60.1 ± 5.2%, p = 0.012), mean pulmonary arterial pressure (mPPA; baseline = 17.4 ± 2.2 mm Hg, rPA ligation = 28.5 ± 5.2 mm Hg, p < 0.001), and arterial partial pressure of carbon dioxide (baseline = 40.4 ± 9.3 mm Hg, rPA ligation = 57.3 ± 12.7 mm Hg, p = 0.026). Of the seven lambs, three were unable to be weaned from mechanical ventilation postoperatively, three were successfully weaned but suffered cardiorespiratory failure within 4 days, and one survived all 4 days. All four animals that were successfully weaned from mechanical ventilation had persistent pulmonary hypertension (mPPA = 28.6 ± 2.2 mm Hg) and remained tachypneic (respiratory rate = 63 ± 21 min). Three of the four recovered lambs required supplemental oxygen. We conclude that rPA ligation creates the physiologic derangements commonly seen in pediatric ESLF and may be suitable for testing and implanting a PAL.
- Subjects :
- medicine.medical_specialty
Respiratory rate
Dead space
medicine.medical_treatment
Hypertension, Pulmonary
Biomedical Engineering
Biophysics
Bioengineering
Pulmonary Artery
Artificial lung
Article
Biomaterials
Internal medicine
medicine
Lung transplantation
Animals
Ligation
Lung
Sheep, Domestic
Mechanical ventilation
Ventilators, Mechanical
business.industry
General Medicine
respiratory system
Right pulmonary artery
Respiration, Artificial
humanities
respiratory tract diseases
Disease Models, Animal
medicine.anatomical_structure
Cardiology
Artificial Organs
business
Respiratory Insufficiency
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7381d3814c4b7f019c4a23c57d345f1a