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Liver Transplantation as Definitive Treatment of Post-cholecystectomy Bile Duct Injury
- Source :
- Annals of Surgery. 275:e729-e732
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- To analyze the perioperative and long-term outcomes of patients undergoing LT due to BDI in a tertiary care center.BDI is associated with significant morbidity and long-term impact on quality of life. LT represents the only possibility of a cure in patients with BDI who develop SBC.Retrospective cohort study from a prospective LT database. Between 2008 and 2019, patients with SBC due to BDI after cholecystectomy and requiring LT were identified. Perioperative and long-term outcomes were analyzed.Among 354 LT, 12 patients underwent LT to treat post-cholecystectomy BDI and accounted for 3.4% of all LT. The median time from BDI to SBC diagnosis was 9.3 years (2.4-14). The mean time from SBC to inclusion on the waitlist was 2.4years (± 2.2). Postoperative complications occurred in 11 patients (91.6%); mainly infectious (9/12 patients, 75%), followed by renal complications (4/12 patients, 33.3%). Only 2 patients developed major complications, which were the patients who died, resulting in a 90-day mortality of 16.7%. After a mean follow-up of 40.3 months (± 42.2) survival at 1, 3, and 5 years was 83%.Although BDI is an unusual indication for LT worldwide, it accounted for 3.4% of all LT in our center. Although postoperative mortality remains high, LT is the only possibility of a cure, with acceptable long-term outcomes. Early referral to a tertiary care center is essential to avoid long-term complications of BDI, such as SBC.
- Subjects :
- medicine.medical_specialty
business.industry
Bile duct
medicine.medical_treatment
Bile Duct Diseases
Liver transplantation
Liver Transplantation
Surgery
medicine.anatomical_structure
Cholecystectomy, Laparoscopic
Quality of Life
medicine
Humans
Cholecystectomy
Bile Ducts
Prospective Studies
business
Retrospective Studies
Volume (compression)
Subjects
Details
- ISSN :
- 15281140 and 00034932
- Volume :
- 275
- Database :
- OpenAIRE
- Journal :
- Annals of Surgery
- Accession number :
- edsair.doi.dedup.....7377d62f6b23cb63e5d5ff898ba747ec