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Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions
- Source :
- Journal of agricultural and food chemistry. 63(5)
- Publication Year :
- 2015
-
Abstract
- Norartocarpetin is a flavone widely distributed in Moraceae plants with strong tyrosinase inhibitory activity. However, its poor solubility in aqueous systems and in food grade solvents (oils) limits its extensive applications. The aim of this study was to improve the solubility of norartocarpetin by developing an oil-in-water (o/w) microemulsion with food grade components. A microemulsion was developed and characterized, and its chemical and physical stabilities were also evaluated within 8 weeks. Using the construction of pseudoternary phase diagrams, the optimized formulation of 2% w/w of ethyl oleate, 12% w/w of Tween 80, 6% w/w of polyethylene glycol 400, and 80% w/w of water was obtained, with a maximum solubility of norartocarpetin up to 1.73 ± 0.21 mg/mL, at least a 1000-fold increase in solubility. The microemulsion base and norartocarpetin-loaded microemulsion were demonstrated to be stable after accelerated and long-term conditions (8 weeks). The norartocarpetin microemulsion still showed strong tyrosinase inhibitory activity and antibrowning effect on fresh-cut apple slices. These combined results indicated that norartocarpetin microemulsion may be suitable as an antibrowning agent for fresh-cut fruits.
- Subjects :
- chemistry.chemical_classification
Chromatography
Aqueous solution
biology
Base (chemistry)
Monophenol Monooxygenase
Plant Extracts
Tyrosinase
Color
General Chemistry
Polyethylene glycol
Moraceae
biology.organism_classification
Flavones
chemistry.chemical_compound
chemistry
Solubility
Microemulsion
Ethyl oleate
Emulsions
Enzyme Inhibitors
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 15205118
- Volume :
- 63
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of agricultural and food chemistry
- Accession number :
- edsair.doi.dedup.....73769864986b2223259612d6e9e6ac0f