Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas

Authors :: Lucile Couronné
Julie Bruneau
François Lemonnier
Tak W. Mak
Philippe Gaulard
Laurianne Scourzic
Olivier A. Bernard
Virginie Fataccioli
Nadine Martin
Rob A. Cairns
A. Dupuy
Elsa Poullot
Laurence de Leval
Source :: Haematologica, vol. 103, no. 3, pp. e115-e118
Publication Year :: 2017
Abstract: Mutations in the epigenetic regulators TET2, IDH2 , and DNMT3A are frequent in peripheral T-cell lymphomas (PTCL), especially in those derived from T follicular helper (TFH) cells. However, the consequences of these alterations on overall levels of 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine

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