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Baseline and Clinical Factors Associated with Response to Amblyopia Treatment in a Randomized Clinical Trial
- Source :
- Optom Vis Sci
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Significance We sought to identify baseline and clinical factors that were predictive of the response to amblyopia treatment. We report that binocular amblyopia treatment may be especially effective for moderate amblyopia in orthotropic children. Purpose We previously reported results from the primary cohort (n = 28) enrolled in a randomized clinical trial (NCT02365090), which found that binocular amblyopia treatment was more effective than patching. Enrollment of an additional 20 children was pre-planned to provide the opportunity to examine factors that may be predictive of response to amblyopia treatment. Methods Forty-eight children (4 to 10 years old) were enrolled, with 24 randomized to contrast-rebalanced binocular game treatment (1 hour a day, 5 days a week) and 24 to patching treatment (2 hours a day, 7 days a week). The primary outcome was change in amblyopic eye best-corrected visual acuity at the 2-week visit. Baseline factors examined were age at enrollment, visual acuity, stereoacuity, and suppression. Clinical factors were etiology, age at diagnosis, prior treatment, and ocular alignment. Results At 2 weeks, visual acuity improvement was significantly greater with the binocular game than patching. Children with moderate amblyopia and orthotropia had more visual acuity improvement with binocular game play than did those with severe amblyopia. In addition, children who spent more time playing the binocular game had more improvement. We were not able to confidently identify any baseline or clinical factors that were associated with response to patching treatment. Conclusions Binocular amblyopia treatment was more effective among orthotropic children with moderate amblyopia than among children with microtropia or severe amblyopia.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Visual acuity
genetic structures
Visual Acuity
Age at diagnosis
Amblyopia
Refraction, Ocular
Article
law.invention
03 medical and health sciences
0302 clinical medicine
Primary outcome
Randomized controlled trial
law
medicine
Humans
Child
Vision, Binocular
business.industry
eye diseases
Ocular alignment
Stereoscopic acuity
Ophthalmology
Treatment Outcome
Video Games
Child, Preschool
Computers, Handheld
Cohort
030221 ophthalmology & optometry
Etiology
Female
Sensory Deprivation
medicine.symptom
business
Orthokeratologic Procedures
030217 neurology & neurosurgery
Follow-Up Studies
Optometry
Subjects
Details
- ISSN :
- 15389235 and 10405488
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Optometry and Vision Science
- Accession number :
- edsair.doi.dedup.....7359a5808eb715b2d4dd42899a2ff0be