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Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation
- Source :
- Cardiovascular Research. 60:131-135
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Background: Tissue factor (TF), the main trigger of coagulation is important in the propagation of cardiovascular diseases. Based on an in vitro study, we hypothesised that enalapril may blunt the endotoxin-induced, TF-triggered coagulation in humans. Methods: In a randomised, controlled trial, 30 healthy male volunteers received 2 ng/kg of lipopolysaccharide (LPS) after pre-treatment with placebo or enalapril for 5 days or with enalapril 2 h before LPS infusion. Results: Infusion of LPS increased interleukin-6 levels 400 fold, and induced a 10-fold increase in prothrombin fragment, a fourfold increase in d-dimer, and a fivefold increase in plasmin–antiplasmin complexes. However, pre-treatment with enalapril did not blunt LPS-induced coagulation. Conclusions: Our trial provides evidence against a modulatory role of angiotensin converting enzyme in LPS-induced, TF-triggered coagulation.
- Subjects :
- Adult
Lipopolysaccharides
Male
medicine.medical_specialty
Physiology
Angiotensin-Converting Enzyme Inhibitors
Statistics, Nonparametric
Thromboplastin
Fibrin Fibrinogen Degradation Products
Tissue factor
Thrombin
Enalapril
Physiology (medical)
Internal medicine
D-dimer
medicine
Humans
Fibrinolysin
Infusions, Intravenous
Analysis of Variance
biology
Interleukin-6
Chemistry
Angiotensin-converting enzyme
Disseminated Intravascular Coagulation
Endocrinology
Coagulation
ACE inhibitor
Leukocytes, Mononuclear
biology.protein
Prothrombin
Cardiology and Cardiovascular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 00086363
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research
- Accession number :
- edsair.doi.dedup.....734e6db1b651b6bcc26986cf98361da4