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Mathematical modelling of COVID-19 disease dynamics: Interaction between immune system and SARS-CoV-2 within host
- Source :
- AIMS Mathematics, Vol 7, Iss 2, Pp 2618-2633 (2022)
- Publication Year :
- 2022
- Publisher :
- AIMS Press, 2022.
-
Abstract
- SARS-COV-2 (Coronavirus) viral growth kinetics within-host become a key fact to understand the COVID-19 disease progression and disease severity since the year 2020. Quantitative analysis of the viral dynamics has not yet been able to provide sufficient information on the disease severity in the host. The SARS-CoV-2 dynamics are therefore important to study in the context of immune surveillance by developing a mathematical model. This paper aims to develop such a mathematical model to analyse the interaction between the immune system and SARS-CoV-2 within the host. The model is developed to explore the viral load dynamics within the host by considering the role of natural killer cells and T-cell. Through analytical simplifications, the model is found well-posed and asymptotically stable at disease-free equilibrium. The numerical results demonstrate that the influx of external natural killer (NK) cells alone or integrating with anti-viral therapy plays a vital role in suppressing the SARS-CoV-2 growth within-host. Also, within the host, the virus can not grow if the virus replication rate is below a threshold limit. The developed model will contribute to understanding the disease dynamics and help to establish various potential treatment strategies against COVID-19.
- Subjects :
- General Mathematics
viruses
mers-cov
Context (language use)
Disease
Computational biology
Biology
medicine.disease_cause
Virus
sars-cov-2
immune system
Immune system
Viral replication
covid-19
basic reproduction number
medicine
QA1-939
Viral load
Host (network)
mathematical model
Mathematics
Coronavirus
Subjects
Details
- Language :
- English
- ISSN :
- 24736988
- Volume :
- 7
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- AIMS Mathematics
- Accession number :
- edsair.doi.dedup.....733d3c03812d945753abd96a9631a09f