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Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α
- Source :
- Heart and Vessels. 34:538-544
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Gold nano-rods, rod-shaped gold nanoparticles, act as contrast agents for in vivo bioimaging, drug delivery vehicles and thermal converters for photothermal therapy. Pro-inflammatory cytokines play critical roles in the development of heart failure. We examined the delivery of GNRs into the failing heart of a transgenic (TG) mouse model of inflammatory cardiomyopathy with the cardiac-specific overexpression of TNF-α. We modified GNRs with polyethylene glycol (PEG) to avoid cytotoxicity and reduce the rapid clearance of nanoparticles from blood. PEG-modified GNRs (4.5 mM as gold atoms, 200 μL) were administered intravenously to TG (n = 7) and wild-type (WT) mice (n = 5). These were killed 24 h later, and the heart, lung, liver, kidney and spleen were excised. A quantitative analysis of gold was performed using inductively coupled plasma mass or optical emission spectrometry. The amount of gold (ng) in the TG heart (3.24 ± 1.56 ng/mg heart weight) was significantly greater than that in the WT heart (1.01 ± 0.19; p
- Subjects :
- Male
Genetically modified mouse
medicine.medical_specialty
Heart Ventricles
Cardiomyopathy
Metal Nanoparticles
Mice, Transgenic
Spleen
030204 cardiovascular system & hematology
Polymerase Chain Reaction
Mice
03 medical and health sciences
0302 clinical medicine
In vivo
Ventricular hypertrophy
Internal medicine
medicine
Animals
030212 general & internal medicine
Heart Failure
Kidney
Tumor Necrosis Factor-alpha
business.industry
Myocardium
DNA
medicine.disease
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Gene Expression Regulation
Colloidal gold
Heart failure
Gold
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 16152573 and 09108327
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Heart and Vessels
- Accession number :
- edsair.doi.dedup.....733aff932b567600b446db7992790cea