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Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double bind randomized clinical trial
- Source :
- Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-12 (2017), Journal of Translational Medicine
- Publication Year :
- 2017
-
Abstract
- Background Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerve. We investigated whether chronic probiotic intake could modulate psychological state, eating behaviour and body composition of normal weight obese (NWO) and preobese–obese (PreOB/OB) compared to normal weight lean women (NWL). Methods 60 women were enrolled. At baseline and after a 3-week probiotic oral suspension (POS) intake, all subjects underwent evaluation of body composition by anthropometry and dual X-ray absorptiometry, and psychological profile assessment by self-report questionnaires (i.e. EDI-2, SCL90R and BUT). Statistical analysis was carried out using paired t test or a non-parametric Wilcoxon test to evaluate differences between baseline and after POS intake, one-way ANOVA to compare all three groups and, where applicable, Chi square or t test were used to assess symptoms. Results Of the 48 women that concluded the study, 24% were NWO, 26% were NWL and 50% were PreOB/OB. Significant differences in body composition were highlighted among groups both at baseline and after a POS (p Conclusions A 3-week intake of selected psychobiotics modulated body composition, bacterial contamination, psychopathological scores of NWO and PreOB/OB women. Further research is needed on a larger population and for a longer period of treatment before definitive conclusions can be made. Trial registration ClinicalTrials.gov Id: NCT01890070
- Subjects :
- 0301 basic medicine
Oral
Adult
Genetics and Molecular Biology (all)
medicine.medical_specialty
Psychometrics
Population
Psychobiotic
Administration, Oral
lcsh:Medicine
Probiotic
Gastroenterology
Biochemistry
Body composition
General Biochemistry, Genetics and Molecular Biology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Chi-square test
Medicine
Humans
Obesity
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
education
education.field_of_study
NWO syndrome
Psychological profile
Female
Probiotics
Body Composition
Body Weight
Biochemistry, Genetics and Molecular Biology (all)
business.industry
Research
lcsh:R
General Medicine
Anthropometry
medicine.disease
030104 developmental biology
Endocrinology
Administration
Defecation
Analysis of variance
business
030217 neurology & neurosurgery
Psychopathology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-12 (2017), Journal of Translational Medicine
- Accession number :
- edsair.doi.dedup.....7338adc964de27097ece4507163642ca