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Effects of Doxycycline Treatment on Hematological and Blood Biochemical Parameters in Dogs Naturally Infected with Ehrlichia canis
- Source :
- Macedonian Veterinary Review, Vol 41, Iss 1, Pp 99-105 (2018)
- Publication Year :
- 2018
- Publisher :
- Walter de Gruyter GmbH, 2018.
-
Abstract
- Ehrlichia canis, the etiologic agent of canine monocytic ehrlichiosis (CME), is mainly transmitted by the brown dog tick Rhipicephalus sanguineus. Clinical signs of the disease can be various, depending on the stage of the disease. Typical changes in hematological and blood biochemical parameters are: severe thrombocytopenia, mild to marked non regenerative anaemia and hypoalbuminemia. In order to present the effects of the treatment protocol on several hematological and biochemistry parameters, 34 Ehrlichia canis positive dogs were compared before and after treatment with doxycycline 10mg/kg/day, in duration of four weeks. Besides the clinical sings and laboratory findings, diagnosis was confirmed by antibody tests (Bionote, Korea, AGROLABO S.p.A., Italy). The most common clinical sings were depression, lethargy, pyrexia, vomiting and anorexia. Hematological analyses were performed on the automatic hematology analyzer Exigo EosVet (Sweden), while biochemistry analyses (alanine aminotransferase, aspartate aminotransferase, urea, creatinine, albumin, total protein, globulin and alkaline phosphatase) were performed using the automatic analyzer ChemWell 2910 (Awareness Technology, INC, USA). Statistically significant difference (pE.canis resulted in significant increase of hematology parameters (red blood cells, hemoglobin, haematocrit and platelets), as well as albumins in serum.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
040301 veterinary sciences
Ehrlichia canis
030106 microbiology
Microbiology
0403 veterinary science
03 medical and health sciences
Internal medicine
medicine
Doxycycline
lcsh:Veterinary medicine
Hematology
doxycycline
General Veterinary
biology
hematology
business.industry
clinical sings
04 agricultural and veterinary sciences
biology.organism_classification
lcsh:SF600-1100
biochemical parameters
business
medicine.drug
Subjects
Details
- ISSN :
- 18577415
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Macedonian Veterinary Review
- Accession number :
- edsair.doi.dedup.....732730326e236a52e29434a370c11a24